Everything you need to know about CBD, from basic science to practical usage. Evidence-based information to help you make informed decisions.
Understanding cannabidiol
Cannabidiol (CBD) is one of over 100 naturally occurring compounds called cannabinoids found in the Cannabis sativa plant. Unlike its more famous cousin THC (tetrahydrocannabinol), CBD is non-intoxicating, meaning it doesn't produce the "high" associated with cannabis use.
CBD was first isolated in 1940 and its structure was fully elucidated in 1963. Since then, extensive research has explored its potential therapeutic applications, leading to increased interest from both the scientific community and the general public.
CBD interacts with the body's endocannabinoid system (ECS), a complex cell-signaling system that plays a role in regulating various physiological processes including:
| Property | CBD | THC |
|---|---|---|
| Psychoactive | No | Yes |
| Legal Status (Federal) | Legal (from hemp) | Controlled substance |
| Drug Testing | Typically not detected | Will show positive |
| Side Effects | Minimal, well-tolerated | Anxiety, impairment |
Evidence-based therapeutic applications
Epidiolex, a purified CBD medication, is approved for treating seizures associated with Lennox-Gastaut syndrome, Dravet syndrome, and tuberous sclerosis complex in patients 1 year and older.
What you need to know
CBD is generally well-tolerated and considered safe by the World Health Organization. However, like any supplement or medication, it can cause side effects in some people.
CBD can interact with many medications by affecting how your body metabolizes them. This is particularly important for drugs with a "grapefruit warning."
How to use CBD effectively
CBD oil or tincture placed under the tongue for 30-60 seconds before swallowing.
CBD consumed in food, beverages, or capsules that pass through the digestive system.
CBD applied directly to the skin for localized relief.
CBD vapor inhaled through vaping devices.
The recommended approach for finding your optimal dose:
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